ODN 1826

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ODN 1826 (CpG 1826) 为 B 类 CpG ODN (寡脱氧核苷酸)，是一种 TLR9 激动剂。ODN 1826 促进细胞凋亡 Apoptosis。ODN 1826 是一种极好的免疫刺激剂，具有抗肿瘤活性。ODN 1826 有保护心脏作用。ODN 1826 序列：5’-tccatgacgttcctgacgtt-3’。

ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’.

Western Blot Analysis Cell Line:RAW 264.7 Concentration:1 μg/mL Incubation Time:24 h Result:Increased the production of NO and iNOS.

Animal Model:Chronic vascular injury mouse models Dosage:18 nM CPG ODN Administration:s.c,three times a week for 7 weeks Result:Increased in aortic atherosclerotic plaque size compared to vehicle.Animal Model:Lewis Lung Cancer Murine Tumor ModelDosage:0.05 mg (1, 3, 5, 8, 11, 13 days) Administration:Intraperitoneal injection (i.p.)Result:Delayed tumor growth,decreased tumor weight and increased the apoptosis of tumor cells.

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Immunology/Inflammation

TLR

TLR | NOS

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202668-42-6

6364.1

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>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 50 mg/mL (7.86 mM; 超声助溶)

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(-20℃)

With Ice Pack

≥ 2 years